The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.

@article{Burtnick2011TheC1,
  title={The cluster 1 type VI secretion system is a major virulence determinant in Burkholderia pseudomallei.},
  author={Mary N. Burtnick and Paul J. Brett and Sarah V. Harding and Sarah A. Ngugi and Wilson J. Ribot and Narisara Chantratita and Angelo Scorpio and Timothy S Milne and Rachel E. Dean and David L Fritz and Sharon J Peacock and Joanne L Prior and Timothy P. Atkins and David DeShazer},
  journal={Infection and immunity},
  year={2011},
  volume={79 4},
  pages={1512-25}
}
The Burkholderia pseudomallei K96243 genome encodes six type VI secretion systems (T6SSs), but little is known about the role of these systems in the biology of B. pseudomallei. In this study, we purified recombinant Hcp proteins from each T6SS and tested them as vaccine candidates in the BALB/c mouse model of melioidosis. Recombinant Hcp2 protected 80% of mice against a lethal challenge with K96243, while recombinant Hcp1, Hcp3, and Hcp6 protected 50% of mice against challenge. Hcp6 was the… CONTINUE READING
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