The clot gene of Drosophila melanogaster encodes a conserved member of the Thioredoxin-like protein superfamily

@article{Giordano2003TheCG,
  title={The clot gene of Drosophila melanogaster encodes a conserved member of the Thioredoxin-like protein superfamily},
  author={E. Giordano and Ivana Peluso and Rosaria Rendina and A F Digilio and M. Furia},
  journal={Molecular Genetics and Genomics},
  year={2003},
  volume={268},
  pages={692-697}
}
The conversion of pyruvoyl-H4-pterin to pyrimidodiazepine (PDA), which is an essential step in the biosynthesis of the red components of Drosophila eye pigments known as drosopterins, requires the products of the genes sepia and clot. While the product of sepia has been shown to correspond to the enzyme PDA-synthase, the role of clot remains unknown, although the clot 1 allele was one of the first eye-color mutants to be isolated in Drosophila melanogaster, and much genetic and biochemical… CONTINUE READING