The close proximity ofEscherichia coli genes: Consequences for stop codon and synonymous codon use

@article{EyreWalker1996TheCP,
  title={The close proximity ofEscherichia coli genes: Consequences for stop codon and synonymous codon use},
  author={Adam Eyre-Walker},
  journal={Journal of Molecular Evolution},
  year={1996},
  volume={42},
  pages={73-78}
}
It is shown that synonymous codon usage is less biased in favor of those codons preferred by highly expressed genes at the end ofEscherichia coli genes than in the middle. This appears to be due to the close proximity of manyE. coli genes. It is shown that a substantial number of genes overlap either the Shine-Dalgarno sequence or the coding sequence of the next gene on the chromosome and that the codons that overlap have lower synonymous codon bias than those which do not. It is also shown… CONTINUE READING