The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family 1

@article{Bonnert1997TheCA,
  title={The cloning and characterization of human MyD88: a member of an IL‐1 receptor related family
 
1},
  author={T. Bonnert and K. Garka and P. Parnet and G. Sonoda and J. Testa and J. Sims},
  journal={FEBS Letters},
  year={1997},
  volume={402}
}
  • T. Bonnert, K. Garka, +3 authors J. Sims
  • Published 1997
  • Biology, Medicine
  • FEBS Letters
  • Murine MyD88, an RNA with homology both to the interleukin‐1 receptor signaling domain and to ‘death‐domains’, is rapidly upregulated during differentiation of the myeloleukemic cell line M1. We have cloned the human homologue of murine MyD88 and re‐evaluated the murine sequence. The open reading frame for both species encodes a 296 amino acid protein, which for murine MyD88 is 53 amino acids longer than originally published. Human MyD88 cDNA is encoded by 5 exons, and maps to chromosome 3p21.3… CONTINUE READING
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