The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution

@article{Krobert2001TheCH,
  title={The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution},
  author={K. Krobert and T. Bach and T. Syversveen and A. Kvingedal and F. Levy},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2001},
  volume={363},
  pages={620-632}
}
Abstract. Serotonin (5-hydroxytryptamine, 5-HT) receptor pre-mRNA is alternatively spliced in human tissue to produce three splice variants, h5-HT7(a), h5-HT7(b) and h5-HT7(d), which differ only in their carboxyl terminal tails. Using membranes from transiently and stably transfected HEK293 cells expressing the three recombinant h5-HT7 splice variants we compared their pharmacological profiles and ability to activate adenylyl cyclase. Using PCR on cDNA derived from various human tissues, the 5… Expand
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143 Citations

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References

SHOWING 1-10 OF 41 REFERENCES
Function and distribution of three rat 5-hydroxytryptamine7 (5-HT7) receptor isoforms produced by alternative splicing
  • 127
Novel brain-specific 5-HT4 receptor splice variants show marked constitutive activity: role of the C-terminal intracellular domain.
  • 181
  • PDF
Identification of a human 5-HT6 receptor variant produced by alternative splicing.
  • 37
Cloning, expression and pharmacology of a truncated splice variant of the human 5‐HT7 receptor (h5‐HT7(b))
  • 115
Cloning, Expression, and Pharmacology of Four Human 5‐Hydroxytryptamine4 Receptor Isoforms Produced by Alternative Splicing in the Carboxyl Terminus
  • 147
5-HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle
  • 110
Human serotonin 5‐HT7 receptor: cloning and pharmacological characterisation of two receptor variants
  • 42
Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation.
  • 572
  • PDF
Functional characterization of the recombinant human 5-hydroxytryptamine7(a) receptor isoform coupled to adenylate cyclase stimulation.
  • 83
  • PDF
Four 5‐Hydroxytryptamine7 (5‐HT7) Receptor Isoforms in Human and Rat Produced by Alternative Splicing: Species Differences Due to Altered Intron‐Exon Organization
  • 210
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