The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution

@article{Krobert2001TheCH,
  title={The cloned human 5-HT7 receptor splice variants: a comparative characterization of their pharmacology, function and distribution},
  author={K. Krobert and T. Bach and T. Syversveen and A. Kvingedal and F. Levy},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2001},
  volume={363},
  pages={620-632}
}
Abstract. Serotonin (5-hydroxytryptamine, 5-HT) receptor pre-mRNA is alternatively spliced in human tissue to produce three splice variants, h5-HT7(a), h5-HT7(b) and h5-HT7(d), which differ only in their carboxyl terminal tails. Using membranes from transiently and stably transfected HEK293 cells expressing the three recombinant h5-HT7 splice variants we compared their pharmacological profiles and ability to activate adenylyl cyclase. Using PCR on cDNA derived from various human tissues, the 5… Expand
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