The clonal composition of a peptide-specific oligoclonal CTL repertoire selected in response to persistent EBV infection is stable over time.

@article{Levitsky1998TheCC,
  title={The clonal composition of a peptide-specific oligoclonal CTL repertoire selected in response to persistent EBV infection is stable over time.},
  author={Victor Levitsky and Pedro Otavio de Campos-Lima and Teresa Frisan and Maria G Masucci},
  journal={Journal of immunology},
  year={1998},
  volume={161 2},
  pages={594-601}
}
The TCR repertoire of a peptide-specific HLA A11-restricted CTL response to persistent infection with EBV was followed for a period of 57 mo. Sequencing of TCR V alpha and V beta chains and alanine scanning mutagenesis analysis of 83 CTL clones isolated in five reactivation experiments demonstrated that this repertoire is composed of at least four distinct CTL clonotypes that are constantly reactivated from donor's blood and express structurally heterogeneous TCRs. Target cell recognition and… CONTINUE READING