The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops

@inproceedings{Pokhilko2012TheCG,
  title={The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops},
  author={Alexandra Pokhilko and Aurora Pi{\~n}as Fern{\'a}ndez and Kieron D. Edwards and Megan M. Southern and Karen J Halliday and Andrew J. Millar},
  booktitle={Molecular systems biology},
  year={2012}
}
Circadian clocks synchronise biological processes with the day/night cycle, using molecular mechanisms that include interlocked, transcriptional feedback loops. Recent experiments identified the evening complex (EC) as a repressor that can be essential for gene expression rhythms in plants. Integrating the EC components in this role significantly alters our mechanistic, mathematical model of the clock gene circuit. Negative autoregulation of the EC genes constitutes the clock's evening loop… CONTINUE READING
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