The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.

@article{Brodowska2014TheCU,
  title={The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation.},
  author={Katarzyna Brodowska and Ahmad Al-Moujahed and Anna Marmalidou and Melissa Meyer Zu Horste and Joanna Cichy and Joan W Miller and Evangelos S. Gragoudas and Demetrios G Vavvas},
  journal={Experimental eye research},
  year={2014},
  volume={124},
  pages={67-73}
}
Verteporfin (VP), a benzoporphyrin derivative, is clinically used in photodynamic therapy for neovascular macular degeneration. Recent studies indicate that VP may inhibit growth of hepatoma cells without photoactivation through inhibition of YAP-TEAD complex. In this study, we examined the effects of VP without light activation on human retinoblastoma cell lines. Verteporfin but not vehicle control inhibited the growth, proliferation and viability of human retinoblastoma cell lines (Y79 and… CONTINUE READING
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