The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

  title={The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.},
  author={Magali Olivier and Anita Langer\od and Patrizia Carrieri and Jonas Bergh and Sigrid Klaar and Jorunn Erla Eyfjord and Charles Theillet and Carmen Arbelo Rodr{\'i}guez and Rosette Lidereau and Ivan Bi{\'e}che and Jennifer Varley and Yves Jean Bignon and Nancy Uhrhammer and Robert Winqvist and Arja Jukkola-Vuorinen and D Niederacher and Shunsuke Kato and Chikashi Ishioka and Pierre Hainaut and Anne-Lise B\orresen-Dale},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 4},
To investigate the clinical value of somatic TP53 mutations in breast cancer, we assembled clinical and molecular data on 1,794 women with primary breast cancer with long-term follow-up and whose tumor has been screened for mutation in exons 5 to 8 of TP53 by gene sequencing. TP53 mutations were more frequent in tumors of ductal and medullar types, aggressive phenotype (high grade, large size, node positive cases, and low hormone receptor content) and in women <60 years old. TP53 mutations… CONTINUE READING
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