The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease

@article{Hoffmann2015TheCU,
  title={The clinical utility of basophil activation testing in diagnosis and monitoring of allergic disease},
  author={Hans J{\"u}rgen Hoffmann and A F Santos and Cristobalina Mayorga and Anna Nopp and Bernadette Eberlein and Marta Ferrer and Paul Rouzaire and D. G. Ebo and Vito Sabato and Mar{\'i}a L Sanz and Tatjana Pecaric-Petkovic and Sarita U. Patil and Oliver V. Hausmann and Wayne G. Shreffler and Peter Koro{\vs}ec and Edward F. Knol},
  journal={Allergy},
  year={2015},
  volume={70},
  pages={1393 - 1405}
}
The basophil activation test (BAT) has become a pervasive test for allergic response through the development of flow cytometry, discovery of activation markers such as CD63 and unique markers identifying basophil granulocytes. Basophil activation test measures basophil response to allergen cross‐linking IgE on between 150 and 2000 basophil granulocytes in <0.1 ml fresh blood. Dichotomous activation is assessed as the fraction of reacting basophils. In addition to clinical history, skin prick… 

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...

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