The clinical uses of leptin.

  title={The clinical uses of leptin.},
  author={Phillip Gorden and Oksana Gavrilova},
  journal={Current opinion in pharmacology},
  volume={3 6},
Leptin is the first of a group of adipocyte-secreted hormones to be used clinically to treat hypoleptinemic states. In children with congenital leptin deficiency and extreme obesity, leptin induces satiety and a dramatic loss of weight. In hypoleptinemic patients with extreme insulin resistance and lipodystrophy, leptin ameliorates insulin resistance, hyperglycemia, hyperinsulinemia, dyslipidemia and hepatic steatosis. In both these leptin-deficient states, leptin therapy restores gonadotrophin… CONTINUE READING