The clinical use of plasma clozapine levels.

  title={The clinical use of plasma clozapine levels.},
  author={R J Bell and Alex McLaren and Jason W Galanos and David Leon Copolov},
  journal={The Australian and New Zealand journal of psychiatry},
  volume={32 4},
OBJECTIVE This review examines the evidence supporting the proposition that a threshold clozapine plasma level can predict clinical response. In addition, it provides a brief overview of the pharmacokinetics, side effects, drug interactions and assay methodology of clozapine. METHOD A comprehensive search of relevant literature was made with respect to the above criteria. The findings were collated and analysed to produce an overview of the usefulness of using clozapine levels in clinical… CONTINUE READING