The clinical trial as a paradigm for epidemiologic research.

@article{Miettinen1989TheCT,
  title={The clinical trial as a paradigm for epidemiologic research.},
  author={Olli S. Miettinen},
  journal={Journal of clinical epidemiology},
  year={1989},
  volume={42 6},
  pages={491-6; discussion 497-8}
}
The extent to which the clinical trial serves, and fails, as a paradigm for epidemiologic research in general is examined. It is argued, first, that the traditional paradigms--investigating epidemic and endemic occurrence of illness in the context of public-health activities, inclusive of the deployment of census, vital and morbidity statistics and sample surveys--are misleading for scientific research. Major examples of the consequences of these paradigms are the preoccupations with time and… CONTINUE READING

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