The clinical toxicology of the designer “party pills” benzylpiperazine and trifluoromethylphenylpiperazine

@article{Schep2011TheCT,
  title={The clinical toxicology of the designer “party pills” benzylpiperazine and trifluoromethylphenylpiperazine},
  author={Leo J. Schep and Robin J Slaughter and J Allister Vale and D Michael G Beasley and Pauline Gee},
  journal={Clinical Toxicology},
  year={2011},
  volume={49},
  pages={131 - 141}
}
Introduction. Benzylpiperazine (BZP) and trifluoromethylphenylpiperazine (TFMPP) are synthetic phenylpiperazine analogues. BZP was investigated as a potential antidepressant in the early 1970s but was found unsuitable for this purpose. More recently, BZP and TFMPP have been used as substitutes for amfetamine-derived designer drugs. They were legally available in a number of countries, particularly in New Zealand, and were marketed as party pills, but are now more heavily regulated. This article… 
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TLDR
The inhibitory effects of BZP and TFMPP observed in this study are of potential significance to clinical practice because CYP2D6, CYP1A2, and CYP3A4 are involved in the metabolism of many commonly used drugs.
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TLDR
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TLDR
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TLDR
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