The clinical toxicology of metamfetamine

@article{Schep2010TheCT,
  title={The clinical toxicology of metamfetamine},
  author={Leo J. Schep and Robin J Slaughter and D Michael G Beasley},
  journal={Clinical Toxicology},
  year={2010},
  volume={48},
  pages={675 - 694}
}
Introduction. Metamfetamine is a highly addictive amfetamine analog that acts primarily as a central nervous system (CNS) stimulant. The escalating abuse of this drug in recent years has lead to an increasing burden upon health care providers. An understanding of the drug's toxic effects and their medical treatment is therefore essential for the successful management of patients suffering this form of intoxication. Aim. The aim of this review is to summarize all main aspects of metamfetamine… Expand
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1
2
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4
5
...

References

SHOWING 1-10 OF 261 REFERENCES
Comment: Serotonin Syndrome, Mydriasis, and Cyproheptadine
TLDR
The clinical features of serotonin syndrome and their time course are clarified and a mechanistic explanation for serotonin toxicity is provided based on cases with atypical serotonergic features and the false premise that mydriasis occurs in all cases of serotonin Syndrome. Expand
Review article: Amphetamines and related drugs of abuse
TLDR
Assessment aims to detect the myriad of possible complications related to acute amphetamine exposure and to institute interventions to limit associated morbidity and mortality. Expand
Cardiac lesions in intravenous drug addicts.
TLDR
Cardiac lesions in drug addicts seem to have a variety of causative factors: infections, toxic influence, hypersensitivity, influence of catecholamines and general hypoxia, and the authors feel that the two latter suggested causes appear most regularly and deserve special attention. Expand
FATAL AMPHETAMINE POISONING.
TLDR
A widespread and increasing use of the amphetamine group of drugs has been of sufficient magnitude to warrant governmental concern and an increasingly large supply is being made available to the public through nonprofessional sources. Expand
Crystal methamphetamine-induced acute pulmonary edema: a case report.
TLDR
The case of a young woman who was admitted to Kaiser Moanalua Medical Center with near fatal acute pulmonary edema consequent to the use of crystal meth is presented. Expand
The bodystuffer syndrome: a clandestine form of drug overdose.
TLDR
A variant of the syndrome is the ingestion of drugs to produce a medical condition that could defer incarceration, which has been called "bodystuffing" by the authors. Expand
Clinical manifestations and prognostic features of acute methamphetamine intoxication.
TLDR
The adverse prognostic features in patients with acute methamphetamine intoxication include coma, shock, convulsion, oliguria, and high core temperature, which are potential risk factors for development of acute renal failure in these patients. Expand
Hyperthermia in psychostimulant overdose.
TLDR
Clinical reports and animal studies indicate that hyperthermia is a primary effect of psychostimulant drugs and can occur independently of seizures or increased motor activity, and activation of particular dopamine receptors in the central nervous system appears to mediate psychostIMulant-inducedhyperthermia. Expand
Influence of activated charcoal on the disposition kinetics of methamphetamine enantiomers in the rat following intravenous dosing.
TLDR
Oral activated charcoal does not enhance the elimination of MAP from the body and is suggested to be a waste of time and money. Expand
Death in amphetamine users: causes and rates.
TLDR
On the basis of the estimated number of regular users of intravenous amphetamine in Ontario, the mortality rate in such users is at least four times as high as in the general population of the same age, and is comparable to that in alcoholics and heroin addicts. Expand
...
1
2
3
4
5
...