The clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol
@article{Schep2012TheCT, title={The clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol}, author={L. Schep and K. Knudsen and R. Slaughter and J. A. Vale and B. M{\'e}garbane}, journal={Clinical Toxicology}, year={2012}, volume={50}, pages={458 - 470} }
Introduction. Gamma-hydroxybutyrate (GHB) and its precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), are drugs of abuse which act primarily as central nervous system (CNS) depressants. In recent years, the rising recreational use of these drugs has led to an increasing burden upon health care providers. Understanding their toxicity is therefore essential for the successful management of intoxicated patients. We review the epidemiology, mechanisms of toxicity, toxicokinetics… CONTINUE READING
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References
SHOWING 1-10 OF 357 REFERENCES
Withdrawal from gamma-hydroxybutyrate, 1,4-butanediol and gamma-butyrolactone: a case report and systematic review.
- Medicine
- CJEM
- 2008
- 84
- PDF
Acute toxicity and withdrawal syndromes related to γ-hydroxybutyrate (GHB) and its analogues γ-butyrolactone (GBL) and 1,4-butanediol (1,4-BD).
- Medicine
- Drug testing and analysis
- 2011
- 42
Gamma-hydroxybutyrate, gamma-butyrolactone, and 1,4-butanediol: a case report and review of the literature.
- Medicine
- Pediatric emergency care
- 2000
- 81
Medical and legal confusion surrounding gamma-hydroxybutyrate (GHB) and its precursors gamma-butyrolactone (GBL) and 1,4-butanediol (1,4BD).
- Medicine
- QJM : monthly journal of the Association of Physicians
- 2008
- 52
- PDF
Adverse events, including death, associated with the use of 1,4-butanediol.
- Medicine
- The New England journal of medicine
- 2001
- 218
Treatment of a 1,4-Butanediol Poisoning with Fomepizole
- Chemistry, Medicine
- Journal of toxicology. Clinical toxicology
- 2002
- 13
Clinical Pharmacology of 1,4‐Butanediol and Gamma‐hydroxybutyrate After Oral 1,4‐Butanediol Administration to Healthy Volunteers
- Medicine
- Clinical pharmacology and therapeutics
- 2007
- 50
Physostigmine as a Treatment for Gamma-Hydroxybutyrate Toxicity: A Review
- Medicine
- Journal of toxicology. Clinical toxicology
- 2002
- 30