The clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol

  title={The clinical toxicology of gamma-hydroxybutyrate, gamma-butyrolactone and 1,4-butanediol},
  author={L. Schep and K. Knudsen and R. Slaughter and J. A. Vale and B. M{\'e}garbane},
  journal={Clinical Toxicology},
  pages={458 - 470}
  • L. Schep, K. Knudsen, +2 authors B. Mégarbane
  • Published 2012
  • Medicine
  • Clinical Toxicology
  • Introduction. Gamma-hydroxybutyrate (GHB) and its precursors, gamma-butyrolactone (GBL) and 1,4-butanediol (1,4-BD), are drugs of abuse which act primarily as central nervous system (CNS) depressants. In recent years, the rising recreational use of these drugs has led to an increasing burden upon health care providers. Understanding their toxicity is therefore essential for the successful management of intoxicated patients. We review the epidemiology, mechanisms of toxicity, toxicokinetics… CONTINUE READING
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