The clinical spectrum and treatment options of macrophage activation syndrome in the pediatric age.

@article{Stabile2006TheCS,
  title={The clinical spectrum and treatment options of macrophage activation syndrome in the pediatric age.},
  author={Achille Stabile and Barbara Bertoni and Valentina Ansuini and Ilaria La Torraca and Ali Salli and Donato Rigante},
  journal={European review for medical and pharmacological sciences},
  year={2006},
  volume={10 2},
  pages={53-9}
}
Macrophage activation syndrome is a rare and potentially fatal complication of many childhood pathological settings, most frequently reported in systemic onset-juvenile idiopathic arthritis. The disruption of the macrophage-lymphocyte interaction leads to uncontrolled proliferation of highly activated macrophages and T lymphocytes. The syndrome comprises a heterogeneous group of disorders featuring sepsis-like characteristics typically combined with impaired function of natural killer cells and… CONTINUE READING
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