The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.

@article{Morishima2002TheCS,
  title={The clinical significance of human leukocyte antigen (HLA) allele compatibility in patients receiving a marrow transplant from serologically HLA-A, HLA-B, and HLA-DR matched unrelated donors.},
  author={Yasuo Morishima and Takehiko Sasazuki and Hidetoshi Inoko and Takeo Juji and Tatsuya Akaza and Ken Yamamoto and Yoshihide Ishikawa and Shunichi Kato and Hiroshi Sao and Hisashi Sakamaki and Keisei Kawa and Nobuyuki Hamajima and Shigetaka Asano and Yoshihisa Kodera},
  journal={Blood},
  year={2002},
  volume={99 11},
  pages={
          4200-6
        }
}
To improve the clinical outcome of allogeneic hematopoietic stem cell transplantation from an unrelated donor, the identification of human leukocyte antigen (HLA) alleles responsible for immunologic events such as graft-versus-host disease (GVHD), engraftment failure, and graft-versus-leukemia effect is essential. Genomic typing of HLA-A, -B, -C, -DRB1, and -DQB1 was retrospectively performed in 1298 donor-patient pairs in cases where marrow was donated from serologically HLA-A, -B, and -DR… CONTINUE READING

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