The clinical significance of circulating tumor cells in the peripheral blood.

@article{Elshimali2006TheCS,
  title={The clinical significance of circulating tumor cells in the peripheral blood.},
  author={Yahya I Elshimali and Wayne W. Grody},
  journal={Diagnostic molecular pathology : the American journal of surgical pathology, part B},
  year={2006},
  volume={15 4},
  pages={187-94}
}
Tumors launch malignant cells into the circulation continuously. In early stages, the immune surveillance system eliminates these cells from the circulation, but at later times they may persist longer and be detected. The first recorded evidence of the presence of circulating tumor cells in the peripheral blood of cancer patients was documented in 1869. Now, modern molecular biologic and cell sorting techniques make their detection and characterization more practicable. This review will… CONTINUE READING

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