The clinical significance and primary determinants of hirsutism in patients with polycystic ovary syndrome.

@article{Panidis2013TheCS,
  title={The clinical significance and primary determinants of hirsutism in patients with polycystic ovary syndrome.},
  author={D. Panidis and K. Tziomalos and E. Papadakis and P. Chatzis and E. Kandaraki and E. Tsourdi and C. Vosnakis and I. Katsikis},
  journal={European journal of endocrinology},
  year={2013},
  volume={168 6},
  pages={
          871-7
        }
}
OBJECTIVE Hirsutism is frequently present in patients with polycystic ovary syndrome (PCOS) and is a major sign of hyperandrogenism. However, other disorders frequently present in PCOS, particularly abdominal obesity and insulin resistance (IR), have also been implicated in the development of hirsutism in this population but relevant data are limited. We aimed to define the determinants of the presence of hirsutism in PCOS. DESIGN Observational study. METHODS We studied 1297 patients with… Expand
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Hirsute patients with PCOS have different clinical characteristics from those that are non-hirsute in terms of BMI, LH, FSH, estradiol, and tT levels and the odds ratios of these different parameters were determined. Expand
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Hirsutism Score and the Severity of Hyperandrogenism Associated with Polycystic Ovary Syndrome in the South-Eastern Region of Turkey
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There was no correlation between serum tT levels and the rate of hirsutism in patients with PCOS, and heritability, testosterone receptor sensitivity, 5α reductase activity or environmental/socioeconomic factors may play a role in the development of clinical hirsUTism. Expand
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It is suggested that the increased responsiveness of the pilo-sebaceous unit to androgens seems to be influenced by insulin sensitivity and that insulin resistance should be assessed in all hirsute women with PCOS regardless of their BMI, as insulin resistance was found in hirsutism irrespective of whether they were overweight or obese. Expand
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PCO appear to be associated with a more pronounced hyperandrogenemia, especially when both ovarian volume and follicle number are increased, especially in women with increased follicle count but normal volume. Expand
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TLDR
Evidence-based diagnostic and treatment strategies that address not only the amelioration of hirsutism but also the treatment of the underlying etiology is essential for the proper management of affected women, especially considering that hirsUTism is, in most cases, a chronic disorder needing long-term follow-up. Expand
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TLDR
Women with PCO have increased circulating androgen levels regardless of the presence or absence of hirsutism and this work has found that serum androstanediol glucuronide (3 alpha-diol G) is markedly increased in idiopathic hirsUTism and it serves as an excellent marker of peripheral androgen metabolism and action. Expand
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TLDR
It is concluded that the three clinical phenotypes of PCOS do not represent forms of the same metabolic disorder and may be the result of varying degrees of metabolic dysfunction; greater degrees of beta-cell function and circulating insulin levels favored the development of hirsutism and frank hyperandrogenemia. Expand
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