The clinical role of circulating free tumor DNA in gastrointestinal malignancy

@article{Howell2017TheCR,
  title={The clinical role of circulating free tumor DNA in gastrointestinal malignancy},
  author={J Howell and Shahid A Khan and Susanne Knapp and Mark R Thursz and Rohini Sharma},
  journal={Translational Research},
  year={2017},
  volume={183},
  pages={137–154}
}
&NA; Circulating cell‐free DNA (cfDNA) is DNA released from necrotic or apoptotic cells into the bloodstream. While both healthy cells and cancer cells release cfDNA, tumors are associated with higher levels of tumor‐derived circulating cell‐free DNA (ctDNA) detectable in blood. Absolute levels of ctDNA and its genetic mutations and epigenetic changes show promise as potentially useful biomarkers of tumor biology, progression, and response to therapy. Moreover, studies have demonstrated the… CONTINUE READING

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