The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis.

@article{Haubrich2002TheCR,
  title={The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis.},
  author={Richard Haubrich and Carol A. Kemper and Nicholas S Hellmann and Philip H. Keiser and Mallory D. Witt and Donald N Forthal and John M. Leedom and Matthew R. Leibowitz and Jeannette M. Whitcomb and Douglas D. Richman and John McCutchan},
  journal={AIDS},
  year={2002},
  volume={16 15},
  pages={F33-40}
}
OBJECTIVE To evaluate the clinical significance of hypersusceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI). DESIGN Analysis of a prospective clinical trial cohort. PATIENTS NNRTI-naive patients failing a stable antiretroviral regimen. MEASUREMENTS HIV phenotype, HIV RNA, and CD4 cell counts were prospectively collected after patients changed to a new regimen. Hypersusceptibility to NNRTI was defined as a fold-change (FC) in IC50 (inhibitory concentration of 50%) of… CONTINUE READING