The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment.


Alzheimer disease (AD) is the most common cause of dementia in the elderly. Clinicopathological studies support the presence of a long preclinical phase of the disease, with the initial deposition of AD pathology estimated to begin approximately 10-15 years prior to the onset of clinical symptoms. The hallmark clinical phenotype of AD is a gradual and… (More)
DOI: 10.1101/cshperspect.a006148