The clinical predictive factors and postoperative histopathological parameters associated with upgrading after radical prostatectomy: A contemporary analysis with grade groups

  title={The clinical predictive factors and postoperative histopathological parameters associated with upgrading after radical prostatectomy: A contemporary analysis with grade groups},
  author={Selçuk Erdem and Samed Verep and Sidar Bağbudar and Yasemin Ozluk and Oner Sanli and Faruk Ozcan},
  journal={The Prostate},
  pages={225 - 234}
Upgrading after radical prostatectomy (RP) is an ongoing problem since first description of Gleason score. In this retrospective study, our aim is to investigate upgrading after RP in grade groups (GG) and clinical predictive, and postoperative histopathological factors associated with GG upgrading (GGU). 
Perineural invasion in prostate needle biopsy: Prognostic value on radical prostatectomy and active surveillance.
The presence of PNI in prostate biopsy is related to adverse anatomopathological factors, being a potential predictor of BCR and have a possible role in the selection of patients for AS.
A novel nomogram provides improved accuracy for predicting biochemical recurrence after radical prostatectomy
By incorporating PSA nadir and MTD into the conventional predictive model, the newly developed nomogram significantly improved the accuracy in predicting BCRFS after RP.
Clinicopathological Characteristics and Prognostic Factors in Axial Chondroblastomas: A Retrospective Analysis of 61 Cases and Comparison with Extra-Axial Chondroblastomas
Overall, ACB and EACB had similar characteristics, except for older age and tumor size, as well as higher Vim expression, incidence of surrounding tissue invasion and postoperative sensory or motor dysfunction, and multivariate analysis of overall survival demonstrated that the type of resection was a significant predictor in the ACB cohort.
The Prostate
  • 2019


Pathological upgrading at radical prostatectomy for patients with Grade Group 1 prostate cancer: implications of confirmatory testing for patients considering active surveillance
To examine the association between National Comprehensive Cancer Network (NCCN) risk, number of positive biopsy cores, age, and early confirmatory test results on pathological upgrading at radical
Radical prostatectomy in men aged ≥70 years: effect of age on upgrading, upstaging, and the accuracy of a preoperative nomogram
To determine the effect of age on clinicopathological features, the accuracy of the preoperative nomogram, and survival after radical retropubic prostatectomy (RRP), as there are limited data on
Prostate biopsy clinical and pathological variables that predict significant grading changes in patients with intermediate and high grade prostate cancer
To identify the clinical and pathological variables that predict pathological changes in the significant proportion of men with prostate cancer who have an intermediate‐ or high‐grade biopsy Gleason
Higher rates of upgrading and upstaging in older patients undergoing radical prostatectomy and qualifying for active surveillance
To determine pathological and oncological outcomes of patients diagnosed with low‐risk prostate cancer in two age cohorts who underwent radical prostatectomy (RP) and qualified for active
The pathological upgrading after radical prostatectomy in low‐risk prostate cancer patients who are eligible for active surveillance: How safe is it to depend on bioptic pathology?
The pathological upgrading after radical prostatectomy (RP) and active surveillance were investigated in patients who were eligible for AS in the present study.
Upgrade in Gleason score between prostate biopsies and pathology following radical prostatectomy significantly impacts upon the risk of biochemical recurrence
Study Type – Prognosis (retrospective cohort) – Positive results (positive results) and negative results (negative results) are consistent with previous studies.
Prognostic Gleason grade grouping: data based on the modified Gleason scoring system
Gleason grades incorporating a prognostic grade grouping which accurately reflect prognosis and are clearly understood by physicians and patients alike are recommended.
Postoperative upgrading of prostate cancer in men ≥75 years: a propensity score-matched analysis
Age ≥75 years, higher PSA levels at RP, and an increased number of positive biopsy cores were predictive for upgrading, and the increased risk of upgrading should be taken into consideration when discussing optimal treatment for this specific cohort.
Correlation of perineural invasion on radical prostatectomy specimens with other pathologic prognostic factors and PSA failure.
PNI is an important prognostic factor that should be taken into consideration in clinical patient management and follow-up after RRP and the presence of PNI together with positive surgical margins and lymph node metastasis may warrant early adjuvant treatment.