The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review

@article{Polcwiartek2015TheCP,
  title={The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review},
  author={Christoffer Polcwiartek and Jimmi Nielsen},
  journal={Psychopharmacology},
  year={2015},
  volume={233},
  pages={741-750}
}
RationaleNew clozapine optimization strategies are warranted, as some patients do not achieve sufficient response and experience various adverse effects. Fluvoxamine is a potent CYP1A2 inhibitor and may increase the ratio of clozapine to its primary metabolite N-desmethylclozapine (NDMC).ObjectivesThis study aims to review all pharmacodynamic effects and the adverse effect profile of changing the clozapine/NDMC ratio with adjunctive fluvoxamine.MethodsMEDLINE, Embase, and the Cochrane Library… 

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