The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic.

@article{Walsh2003TheCP,
  title={The clinical pharmacology of buprenorphine: extrapolating from the laboratory to the clinic.},
  author={Sharon L. Walsh and Thomas E Eissenberg},
  journal={Drug and alcohol dependence},
  year={2003},
  volume={70 2 Suppl},
  pages={
          S13-27
        }
}
This paper will review clinical pharmacology studies on buprenorphine, a mixed opioid agonist-antagonist currently approved as a treatment for opioid dependence. The focus is on studies characterizing buprenorphine's pharmacodynamic actions, including its safety, abuse liability, withdrawal suppression and withdrawal precipitation capacity, physical dependence potential, cross-tolerance and duration of action as well as a review of the pharmacological profile of buprenorphine/naloxone… CONTINUE READING
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