The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.

@article{Gupta2005TheCP,
  title={The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction.},
  author={Manish K. Gupta and Andreas Kovar and Bernd Meibohm},
  journal={Journal of clinical pharmacology},
  year={2005},
  volume={45 9},
  pages={987-1003}
}
Differences in the clinical pharmacology of the 3 currently available oral phosphodiesterase-5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, are largely determined by their clinical pharmacokinetics as well as their PDE inhibitory activity profile. This review comparatively discusses the major characteristics of the pharmacokinetic profile of all 3 PDE5 inhibitors, including bioavailability and rate of absorption, Biopharmaceutical Classification System categorization, elimination… CONTINUE READING
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