The clinical outcomes of undifferentiated pleomorphic sarcoma (UPS): A single-centre experience of two decades with the assessment of PD-L1 expressions.

@article{Lee2020TheCO,
  title={The clinical outcomes of undifferentiated pleomorphic sarcoma (UPS): A single-centre experience of two decades with the assessment of PD-L1 expressions.},
  author={Kyoungmin Lee and Joon Seon Song and Jeong Eun Kim and Wanlim Kim and Si Yeol Song and Min Hee Lee and Hye Won Chung and Kyung-Ja Cho and Jong-Seok Lee and Jin-Hee Ahn},
  journal={European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology},
  year={2020}
}
  • Kyoungmin Lee, J. Song, Jin-Hee Ahn
  • Published 24 February 2020
  • Medicine
  • European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Undifferentiated pleomorphic sarcoma of the extremity and trunk: a retrospective cohort study of 166 cases in a large institution
TLDR
The existing study reveals that the UPS in trunk, tumor size ≥5 cm and R1/R2 resection margin are the prognostic markers of poor survival rate, which was correlated with LRFS, DMFS, and OS.
Undifferentiated Pleomorphic Sarcoma of the Extremity and Trunk: A Retrospective Cohort Study of 166 Cases in a Large Institution
TLDR
R0 resection margin was an only independent favorable prognostic factor, which was correlated with LRFS, DMFS, and OS, and reveals that the UPS in trunk and R1/R2 resectionmargin are the prognostic markers of poor survival rate.
Undifferentiated Pleomorphic Sarcoma with Neoplastic Fever: A Retrospective Study
TLDR
This study retrospectively analyzed the clinical data of patients with UPS to provide a reference for the diagnosis and treatment of UPS with neoplastic fever, which is characterized by intratumoral necrosis and extensive edema of the surrounding soft tissues.
Novel Nomograms-Based Prediction Models for Patients with Primary Undifferentiated Pleomorphic Sarcomas Resections
TLDR
Two nomograms are developed that are able to predict 3- and 5-year overall survival (OS) and time to recurrence (TTR) for UPS patients for the first time and show relatively good accuracy and practicability.
Serum lactate dehydrogenase as a novel prognostic factor for patients with primary undifferentiated pleomorphic sarcomas
TLDR
Preoperative serum LDH is an independent factor for OS in UPS patients, and it correlates with future surgical margin, and Kaplan–Meier curves showed that patients with relatively high-serum LDH had poorer OS compared with those with low-seru LDH.
The potentiality of immunotherapy for sarcomas: a summary of potential predictive biomarkers.
TLDR
Potential biomarkers of immunotherapy for treatment of sarcomas focused on PD-1/PD-L1 inhibitors, which play a crucial role in the progression of tumor by altering status of immune surveillance.
Giant pleomorphic sarcoma of the tongue base – a cured clinical case report and literature review
TLDR
This case presented surprisingly a favorable evolution despite the huge dimensions, the tumor type, and associated pathology, and the evolution was without relapse after 18 months.
Facts and Hopes in Immunotherapy of Soft-Tissue Sarcomas
TLDR
The facts and the hopes for the patients with sarcoma are presented, as the field is rapidly advancing its understanding of what and where to use the various types of immunotherapies.
Undifferentiated Pleomorphic Sarcoma

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