The clinical importance of neutralizing antibodies in relapsing-remitting multiple sclerosis.

@article{Namaka2006TheCI,
  title={The clinical importance of neutralizing antibodies in relapsing-remitting multiple sclerosis.},
  author={Michael Namaka and Merinda Pollitt-Smith and Aneri Gupta and Meghann Klowak and Marcus Barreto Vasconcelos and Dana Turcotte and Yuewen Gong and Maria Melanson},
  journal={Current medical research and opinion},
  year={2006},
  volume={22 2},
  pages={223-39}
}
BACKGROUND Neutralizing antibodies (NAbs) develop in patients receiving interferon beta (IFN-beta) for multiple sclerosis (MS). Debate continues concerning the relevance of NAb development on treatment efficacy. OBJECTIVE To determine the incidence and clinical importance of NAbs in patients with relapsing-remitting MS (RRMS). METHODS A comprehensive literature review was conducted using PubMed (accessed from 1983 to June 2005), Cochrane MS Group trials register (accessed June 2005… CONTINUE READING

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