The clinical consequences of strain diversity in Mycobacterium tuberculosis.

  title={The clinical consequences of strain diversity in Mycobacterium tuberculosis.},
  author={Mark P Nicol and Robert J Wilkinson},
  journal={Transactions of the Royal Society of Tropical Medicine and Hygiene},
  volume={102 10},
The influence of strain variation on the outcome of infection with Mycobacterium tuberculosis is an emerging area of research. Significant genetic diversity is generated within the species through deletion, duplication and recombination events; however, unlike many bacterial pathogens gene exchange is rare in M. tuberculosis, resulting in the evolution of distinct clonal lineages. One such lineage, W-Beijing, is particularly virulent in animal models, may be emerging worldwide, has distinct… CONTINUE READING

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