The clinical challenge of bridging anticoagulation with low-molecular-weight heparin in patients with mechanical prosthetic heart valves: an evidence-based comparative review focusing on anticoagulation options in pregnant and nonpregnant patients.

@article{Seshadri2005TheCC,
  title={The clinical challenge of bridging anticoagulation with low-molecular-weight heparin in patients with mechanical prosthetic heart valves: an evidence-based comparative review focusing on anticoagulation options in pregnant and nonpregnant patients.},
  author={Niranjan Seshadri and Samuel Z. Goldhaber and Uri Elkayam and Richard A. Grimm and James B. Groce and John A Heit and Sarah A. Spinler and AlexanderG. G. Turpie and Gideon Bosker and Allan L. Klein},
  journal={American heart journal},
  year={2005},
  volume={150 1},
  pages={
          27-34
        }
}
BACKGROUND Recent labeling changes for enoxaparin, a low-molecular-weight heparin (LMWH), have prompted a reexamination of its role in patients with mechanical prosthetic heart valves (MPHVs). Healthcare providers are faced with the challenge of weighing favorable trial results with LMWHs and balancing their clinical experiences with these agents as a bridge to oral anticoagulation in patients with prosthetic heart valves. This review will provide evidence-based guidance on issues surrounding… CONTINUE READING
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