The clinical applications of human amnion in plastic surgery.

@article{Fairbairn2014TheCA,
  title={The clinical applications of human amnion in plastic surgery.},
  author={Neil G. Fairbairn and Mark A Randolph and Robert W. Redmond},
  journal={Journal of plastic, reconstructive \& aesthetic surgery : JPRAS},
  year={2014},
  volume={67 5},
  pages={
          662-75
        }
}
Since the early 1900s, human amnion has been applied to a wide variety of clinical scenarios including burns, chronic ulcers, dural defects, intra-abdominal adhesions, peritoneal reconstruction, genital reconstruction, hip arthroplasty, tendon repair, nerve repair, microvascular reconstruction, corneal repair, intra-oral reconstruction and reconstruction of the nasal lining and tympanic membrane. Amnion epithelial and mesenchymal cells have been shown to contain a variety of regulatory… Expand

Paper Mentions

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This is a randomised trial that aims to evaluate whether a transient skin cover made out of human amniotic membranes is effective in managing burns among pediatric patients. The primary… Expand
ConditionsBurns
InterventionBiological, Device, Procedure
Interventional Clinical Trial
The purpose of this research study is to find our if human amnion membrane powder can be safely used as a covering for wounds and can improve the condition of skin graft donor sites… Expand
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InterventionDrug, Procedure
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Tendon adhesions of the hand remain a ubiquitous problem facing hand surgeons and hand therapists alike. Despite their commonality, no consensus exists as to the best means of… Expand
ConditionsAdhesions Nos Postoperative, Fibrosis, Scar, (+1 more)
InterventionBiological, Procedure
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This pilot study demonstrates that dehydrated amniotic membrane allograft can be safely utilized as an adjunct during dural closures for craniotomies and transsphenoidal surgeries. Expand
Transplantation of human amnion prevents recurring adhesions and ameliorates fibrosis in a rat model of sciatic nerve scarring.
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It is concluded that hAM is strongly effective against recurring nerve scarring and induces an anti-fibrotic and pro-regenerative effect, making it highly promising for treating adhesion-related disorders. Expand
Use of cryopreserved human amniotic membrane in the treatment of skin ulcers secondary to calciphylaxis
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An innovative treatment for skin ulcers secondary to calciphylaxis is presented using cryopreserved amniotic membrane (AM) as a dressing in order to promote epithelialization of the wounds and reduce pain in a 67‐year‐old male patient with end stage renal disease. Expand
Applications of materials for dural reconstruction in pre-clinical and clinical studies: Advantages and drawbacks, efficacy, and selections.
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This review comprehensively summarizes the characteristics and efficacy of these dural substitutes, especially in clinical applications, including the advantages and drawbacks of those from different sources, the host tissue response in pre-clinical studies and clinical practice, and the comparison of these materials across different surgical procedures. Expand
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The data supports the use of vCUT as an adhesion barrier in surgical procedures after post-operative adhesions in rabbits using a rabbit abdominal adhesion model. Expand
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References

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Amniotic membrane induces epithelialization in massive posttraumatic wounds
TLDR
AM substantially modifies the behavior of keratinocytes in chronic wounds, thereby allowing effective reepithelialization, and the use of AM as a wound dressing in two patients with large and deep traumatic wounds is reported. Expand
Amniotic membrane: from structure and functions to clinical applications
TLDR
AM is a promoter of epithelialization and is a non-tumorigenic tissue and its use has no ethical problems, and it has been applied in several surgical procedures related to ocular surface reconstruction and the genito-urinary tract, skin, head and neck, among others. Expand
Autologous amnion graft for repair of myelomeningocele: technical note and clinical implication
TLDR
A novel repair technique using autologous amnion graft, which has no risks of rejection, foreign body reaction, or transmission of slow virus infection to reconstruct the lesion of newborn patient is introduced. Expand
Preservation, sterilization and de-epithelialization of human amniotic membrane for use in ocular surface reconstruction.
TLDR
The present techniques and several novel, new approaches in the preparation of AM for use in ocular surface reconstruction, and their impact on AM structure and biological activity are discussed. Expand
Ophthalmic Applications of Preserved Human Amniotic Membrane: A Review of Current Indications
TLDR
It is shown that remarkable improvements in surface stability have resulted from concurrent AMT and limbal stem cell transplantation, wherein the limbal grafts are obtained from the normal fellow eye, living relative or cadaveric eye. Expand
The effect of nonpreserved human amniotic membrane on the survival of ischaemic skin flaps in rats.
TLDR
This study showed that amniotic membrane could improve the survival rate of ischaemic skin flaps and showed many more blood vessels and fewer neutrophils in the FA and FAT groups than in the F and FT groups. Expand
Use of Human Amnion for Microvascular Interpositional Grafts
TLDR
Tubed conduits of glutaraldehyde-treated amnion were hand constructed of varying diameters and lengths and employed as segmental interpositional grafts in experimentally created femoral and aortic arterial defects in Sprague-Dawley rats. Expand
Effect of fresh human amniotic membrane dressing on graft take in patients with chronic burn wounds compared with conventional methods.
TLDR
It is shown that human amniotic membrane dressing significantly increases the success rate of graft take in chronic wounds, and it can be recommended as an important dressing in chronic burn wounds management, due to interesting anti-microbial, and better graft take effects. Expand
Rolling the human amnion to engineer laminated vascular tissues.
TLDR
A multilaminate rolling approach using the human amnion to generate a tubular construct for blood vessel regeneration that has the ability to rapidly produce a cell-dense construct with an extracellular matrix similar in architecture and composition to natural vessels. Expand
Use of Banked Tissue in Plastic Surgery
TLDR
Lyophilised, irradiated, human amnion is a temporary biological dressing conveniently available off-the-shelf that was used in twenty four patients with burns, eight patients with bedsores and six patients with non-healing ulcers mainly on the foot. Expand
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