The clinical application of a new specific functional assay to detect the factor V(Leiden) mutation associated with activated protein C resistance.

Abstract

Resistance to activated protein C (APC) is the most common defect found in patients who have venous thromboembolism. The molecular basis of APC resistance is a single-point mutation (arginine506-glutamine) in the gene that encodes for coagulation factor V. This mutation results in a factor V molecule (factor V(Leiden)) that is less effectively downregulated… (More)

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@article{Oerle1997TheCA, title={The clinical application of a new specific functional assay to detect the factor V(Leiden) mutation associated with activated protein C resistance.}, author={Ren{\'e} van van Oerle and Lizzy C M van Pampus and Guido Tans and Jan Rosing and Karli Hamulyak}, journal={American journal of clinical pathology}, year={1997}, volume={107 5}, pages={521-6} }