• Corpus ID: 53535815

The clinical DELTA-P score accurately predicts small cell lung cancer in the Lambert-Eaton myasthenic syndrome

@inproceedings{Titulaer2010TheCD,
  title={The clinical DELTA-P score accurately predicts small cell lung cancer in the Lambert-Eaton myasthenic syndrome},
  author={M. J. Titulaer and Paul Maddison and J K Sont and P. W. Wirtz and David Hilton‐Jones and Rinse Klooster and Nick Willcox and Marko Potman and P. Sillevis Smitt and Jbm Kuks and B. O. Roep and Angela Vincent and S. M. van der Maarel and J. B. Van Dijk and Bethan Lang and J. J. Verschuuren},
  year={2010}
}
Introduction Approximately one half of patients with Lambert-Eaton myasthenic syndrome (LEMS) have small cell lung carcinomas (SCLC), aggressive tumours with poor prognosis. In view of its profound impact on therapy and survival, we developed and validated a score to identify the presence of SCLC early in the course of LEMS. Patients and methods We derived a prediction score for SCLC in LEMS in a nationwide cohort of 107 Dutch patients, and validated it in a similar cohort of 112 British… 

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References

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PURPOSE A small-cell lung carcinoma (SCLC) is found in 50% of patients with Lambert-Eaton myasthenic syndrome (LEMS). We evaluated screening to optimize screening strategy for SCLC. It is important

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TLDR
SOX antibodies have diagnostic value in discriminating SCLC-LEMS from nontumor LEMS, but have no relation to survival in patients with SclC.

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TLDR
The presence of a particular symptom associated with LEMS did not predict the presence of SCLC, but in patients with rapidly progressive LEMS the possibility of underlying lung cancer should be of particular concern.

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TLDR
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TLDR
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SOX1 antibodies are markers of paraneoplastic Lambert–Eaton myasthenic syndrome

TLDR
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