The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.

@article{Talbot2014TheCC,
  title={The cleaved cytoplasmic tail of polycystin-1 regulates Src-dependent STAT3 activation.},
  author={Jeffrey J. Talbot and Xuewen W. Song and Xiaofang Wang and Markus M Rinschen and Nicholas Doerr and Wells B LaRiviere and Bernhard Schermer and York P Pei and Vicente E. Torres and Thomas Weimbs},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2014},
  volume={25 8},
  pages={1737-48}
}
Polycystin-1 (PC1) mutations result in proliferative renal cyst growth and progression to renal failure in autosomal dominant polycystic kidney disease (ADPKD). The transcription factor STAT3 (signal transducer and activator of transcription 3) was shown to be activated in cyst-lining cells in ADPKD and PKD mouse models and may drive renal cyst growth, but the mechanisms leading to persistent STAT3 activation are unknown. A proteolytic fragment of PC1 corresponding to the cytoplasmic tail, PC1… CONTINUE READING
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