The cleavage of the urokinase receptor regulates its multiple functions.

Abstract

The urokinase-type plasminogen activator (uPA) is able to cleave its cell surface receptor (uPAR) anchored to the cell membrane through a glycophosphatidylinositol tail. The cleavage leads to the formation of cell surface truncated forms, devoid of the N-terminal domain 1 (D1) and unmasks or disrupts, depending on the cleavage site, a sequence in the D1-D2… (More)

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@article{Montuori2002TheCO, title={The cleavage of the urokinase receptor regulates its multiple functions.}, author={Nunzia Montuori and Maria Vincenza Carriero and Salvatore Salzano and Guido Rossi and Pia Ragno}, journal={The Journal of biological chemistry}, year={2002}, volume={277 49}, pages={46932-9} }