The clearance of manganese chloride in the primate.

@article{Newland1987TheCO,
  title={The clearance of manganese chloride in the primate.},
  author={M C Newland and Christopher Cox and Rikuzo Hamada and G{\"u}nther Oberd{\"o}rster and Bernard Weiss},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1987},
  volume={9 2},
  pages={314-28}
}
Two macaque monkeys inhaled trace amounts of 54MnCl2 for 30 min. Subsequently the chest, head, and fecal radioactivity were monitored for over a year. The chest data curve required a sum of three exponential terms, with half-times ranging from 0.2 to 187 days, to attain a satisfactory fit. Head levels peaked 40 days after acute inhalation exposure and remained elevated for over a year. The excretion of manganese through the feces was best described by a sum of two exponentials. One had a half… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 39 extracted citations

Analysis of manganese tracer kinetics and target tissue dosimetry in monkeys and humans with multi-route physiologically based pharmacokinetic models.

Toxicological sciences : an official journal of the Society of Toxicology • 2011
View 12 Excerpts
Highly Influenced

Tissue manganese concentrations in young male rhesus monkeys following subchronic manganese sulfate inhalation.

Toxicological sciences : an official journal of the Society of Toxicology • 2006
View 2 Excerpts
Highly Influenced

T1 Relaxation Rate (R1) Indicates Nonlinear Mn Accumulation in Brain Tissue of Welders With Low-Level Exposure.

Toxicological sciences : an official journal of the Society of Toxicology • 2015
View 2 Excerpts

Similar Papers

Loading similar papers…