The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency

Abstract

4-Nitroquinoline 1-oxide (4NQO) is used as a positive control in various genotoxicity assays because of its known mutagenic and carcinogenic properties. The chemical is converted into 4-hydroxyaminoquinoline 1-oxide and gives rise to three main DNA adducts, N-(deoxyguanosin-8-yl)-4AQO, 3-(desoxyguanosin-N (2)-yl)-4AQO and 3-(deoxyadenosin-N (6)-yl)-4AQO… (More)
DOI: 10.1093/mutage/gev069

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Cite this paper

@inproceedings{Brsehafer2016TheCO, title={The clastogenicity of 4NQO is cell-type dependent and linked to cytotoxicity, length of exposure and p53 proficiency}, author={Katja Br{\"{u}sehafer and Bella B Manshian and Ann Teresa Doherty and Zoulikha M. Za{\"{i}r and George E Johnson and Shareen Heather Doak and Gareth J. S. Jenkins}, booktitle={Mutagenesis}, year={2016} }