The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.

@article{Parr1998TheCM,
  title={The classical mouse mutant postaxial hemimelia results from a mutation in the Wnt 7a gene.},
  author={Brian A. Parr and E J Avery and J A Cygan and Andrew P. McMahon},
  journal={Developmental biology},
  year={1998},
  volume={202 2},
  pages={228-34}
}
The study of spontaneous mutations has aided the understanding of developmental processes. A large collection of spontaneous or "classical" mouse mutations has been accumulated over many decades. One of the mutations causes the postaxial hemimelia (px) phenotype, which consists of limb patterning defects accompanied by Müllerian duct-associated sterility in both sexes. We were intrigued that both the limb and the Müllerian duct px phenotypes are similar to those caused by mutations in the gene… CONTINUE READING

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Copyright © 1998 by Academic Press. All rights of reproduction in any form reserved

  • Parr
  • 1998

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