The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination.

@article{March1993TheCH,
  title={The classical human phosphoglucomutase (PGM1) isozyme polymorphism is generated by intragenic recombination.},
  author={Ruth E March and Wendy E Putt and M Hollyoake and Jane H. Ives and Jennifer U Lovegrove and David A. Hopkinson and Yvonne H. Edwards and David B Whitehouse},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1993},
  volume={90 22},
  pages={10730-3}
}
The molecular basis of the classical human phosphoglucomutase 1 (PGM1) isozyme polymorphism has been established. In 1964, when this genetic polymorphism was first described, two common allelozymes PGM1 and PGM1 2 were identified by starch gel electrophoresis. The PGM1 2 isozyme showed a greater anodal electrophoretic mobility than PGM1 1. Subsequently, it was found that each of these allelozymes could be split, by isoelectric focusing, into two subtypes; the acidic isozymes were given the… CONTINUE READING

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