The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi.

@article{Ferreira2004TheCA,
  title={The classical activation pathway of the human complement system is specifically inhibited by calreticulin from Trypanosoma cruzi.},
  author={Viviana P. Ferreira and Carolina E Valck and Gittith S{\'a}nchez and Alexandre Gingras and Sotiria Tzima and Maria Del Carmen Bisi Molina and Robert Sim and Wilhelm Schwaeble and A dos S Ferreira},
  journal={Journal of immunology},
  year={2004},
  volume={172 5},
  pages={3042-50}
}
The high resistance of Trypanosoma cruzi trypomastigotes, the causal agent of Chagas' disease, to complement involves several parasite strategies. In these in vitro studies, we show that T. cruzi calreticulin (TcCRT) and two subfragments thereof (TcCRT S and TcCRT R domains) bind specifically to recognition subcomponents of the classical and lectin activation pathways (i.e., to collagenous tails of C1q and to mannan-binding lectin) of the human complement system. As a consequence of this… CONTINUE READING
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