The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.

@article{McLeod2011TheCI,
  title={The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.},
  author={Ian X. McLeod and Xiang Zhou and Qi-jing Li and Fan Wang and Y. N. He},
  journal={Journal of immunology},
  year={2011},
  volume={187 10},
  pages={5051-61}
}
IL-7Rα-mediated signals are essential for naive T lymphocyte survival. Recent studies show that IL-7Rα is internalized and either recycled to cell surface or degraded. However, how the intracellular process of IL-7Rα trafficking is regulated is unclear. In this paper, we show that Vps34, the class III PI3K, plays a critical role in proper IL-7Rα intracellular trafficking. Mice lacking Vps34 in T lymphocytes had a severely reduced T lymphocyte compartment. Vps34-deficient T lymphocytes exhibit… CONTINUE READING
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