The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate.

@article{Ballard1967TheCC,
  title={The citrate cleavage pathway and lipogenesis in rat adipose tissue: replenishment of oxaloacetate.},
  author={F. John Ballard and Richard W. Hanson},
  journal={Journal of lipid research},
  year={1967},
  volume={8 2},
  pages={73-9}
}
Fatty acid synthesis via the citrate cleavage pathway requires the continual replenishment of oxaloacetate within the mitochondria, probably by carboxylation of pyruvate. Malic enzyme, although present in adipose tissue, is completely localized in the cytoplasm and has insufficient activity to support lipogenesis. Pyruvate carboxylase was found to be active in both the mitochondria and cytoplasm of epididymal adipose tissue cells; it was dependent on both ATP and biotin. Alteractions in dietary… CONTINUE READING