The circulatory systemic environment as a modulator of neurogenesis and brain aging.

@article{Villeda2013TheCS,
  title={The circulatory systemic environment as a modulator of neurogenesis and brain aging.},
  author={Saul A Villeda and Tony Wyss-Coray},
  journal={Autoimmunity reviews},
  year={2013},
  volume={12 6},
  pages={674-7}
}
The ability of the adult brain to generate newly born neurons dramatically declines during aging, and has even been proposed to contribute, in part, to age-related cognitive impairments. While intrinsic molecular mechanisms underlying decreased neurogenesis during aging have begun to be elucidated, relatively little is still known as to the contribution of the systemic environment. Interestingly, immune signaling has quickly emerged as a key negative regulator of adult neurogenesis, and has… CONTINUE READING
16 Citations
39 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

References

Publications referenced by this paper.

Similar Papers

Loading similar papers…