The circulatory and renal sympathoinhibitory effects of gastric leptin are altered by a high fat diet and obesity.

Abstract

Gastric leptin elicits its cardiovascular and splanchnic sympathoinhibitory responses via a vagal afferent mechanism, however the latter are blunted/abolished in animals fed a medium high fat diet (MHFD). In a diet-induced obesity model we sought to determine whether the renal sympathetic nerve discharge (RSND) and regional vasodilator responses to gastric… (More)
DOI: 10.1016/j.autneu.2013.02.018

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