The circulating transcriptome as a source of non-invasive cancer biomarkers: concepts and controversies of non-coding and coding RNA in body fluids

@inproceedings{FernndezMercado2015TheCT,
  title={The circulating transcriptome as a source of non-invasive cancer biomarkers: concepts and controversies of non-coding and coding RNA in body fluids},
  author={Marta Fern{\'a}ndez-Mercado and Lorea Manterola and Erika Larrea and Ibai Goicoechea and Mar{\'i}a Arest{\'i}n and Mar{\'i}a Armesto and David Otaegui and Charles Henderson Lawrie},
  booktitle={Journal of cellular and molecular medicine},
  year={2015}
}
The gold standard for cancer diagnosis remains the histological examination of affected tissue, obtained either by surgical excision, or radiologically guided biopsy. Such procedures however are expensive, not without risk to the patient, and require consistent evaluation by expert pathologists. Consequently, the search for non-invasive tools for the diagnosis and management of cancer has led to great interest in the field of circulating nucleic acids in plasma and serum. An additional benefit… CONTINUE READING
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