The circadian rhythm controls telomeres and telomerase activity.

  title={The circadian rhythm controls telomeres and telomerase activity.},
  author={Wei-Dar Chen and Ming-Shien Wen and Shian-Sen Shie and Yu-Lun Lo and Hung-Ta Wo and Chun-Chieh Wang and I-Chang Hsieh and Tsong-Hai Lee and Chao-Yung Wang Wang},
  journal={Biochemical and biophysical research communications},
  volume={451 3},
Circadian clocks are fundamental machinery in organisms ranging from archaea to humans. Disruption of the circadian system is associated with premature aging in mice, but the molecular basis underlying this phenomenon is still unclear. In this study, we found that telomerase activity exhibits endogenous circadian rhythmicity in humans and mice. Human and mouse TERT mRNA expression oscillates with circadian rhythms and are under the control of CLOCK-BMAL1 heterodimers. CLOCK deficiency in mice… CONTINUE READING
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