The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.

@article{Eide2002TheCR,
  title={The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.},
  author={Erik J. Eide and Erica L. Vielhaber and William A Hinz and David M Virshup},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 19},
  pages={17248-54}
}
The serine/threonine protein kinase casein kinase I epsilon (CKIepsilon) is a key regulator of metazoan circadian rhythm. Genetic and biochemical data suggest that CKIepsilon binds to and phosphorylates the PERIOD proteins. However, the PERIOD proteins interact with a variety of circadian regulators, suggesting the possibility that CKIepsilon may interact with and phosphorylate additional clock components as well. We find that CRY1 and BMAL1 are phosphoproteins in cultured cells. Mammalian… CONTINUE READING
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