The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

@article{PekovicVaughan2014TheCC,
  title={The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.},
  author={Vanja Pekovic-Vaughan and Julie Gibbs and Hikari Yoshitane and Nan Yang and Dharshika Pathiranage and Baoqiang Guo and Aya Sagami and Keiko Taguchi and David A Bechtold and Andrew Loudon and Masayuki Yamamoto and Jefferson Chan and Gijsbertus T. J. van der Horst and Yoshitaka Fukada and Qing-Jun Meng},
  journal={Genes & development},
  year={2014},
  volume={28 6},
  pages={
          548-60
        }
}
The disruption of the NRF2 (nuclear factor erythroid-derived 2-like 2)/glutathione-mediated antioxidant defense pathway is a critical step in the pathogenesis of several chronic pulmonary diseases and cancer. While the mechanism of NRF2 activation upon oxidative stress has been widely investigated, little is known about the endogenous signals that regulate the NRF2 pathway in lung physiology and pathology. Here we show that an E-box-mediated circadian rhythm of NRF2 protein is essential in… CONTINUE READING
Highly Cited
This paper has 46 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 29 citations

References

Publications referenced by this paper.
Showing 1-10 of 55 references