The circadian clock mutation alters sleep homeostasis in the mouse.

  title={The circadian clock mutation alters sleep homeostasis in the mouse.},
  author={Emma Naylor and Bernard M Bergmann and Kristyn R. Krauski and Phyllis C Zee and Joseph S Takahashi and Martha H Vitaterna and Fred W Turek},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={20 21},
The onset and duration of sleep are thought to be primarily under the control of a homeostatic mechanism affected by previous periods of wake and sleep and a circadian timing mechanism that partitions wake and sleep into different portions of the day and night. The mouse Clock mutation induces pronounced changes in overall circadian organization. We sought to determine whether this genetic disruption of circadian timing would affect sleep homeostasis. The Clock mutation affected a number of… CONTINUE READING

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Molecular cloning and characterization

  • RY, JS Takahashi
  • 1999

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